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首页> 外文OA文献 >The botrydial biosynthetic gene cluster of Botrytis cinerea displays a bipartite genomic structure and is positively regulated by the putative Zn(II)(2)Cys(6) transcription factor BcBot6
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The botrydial biosynthetic gene cluster of Botrytis cinerea displays a bipartite genomic structure and is positively regulated by the putative Zn(II)(2)Cys(6) transcription factor BcBot6

机译：灰葡萄孢的葡萄球菌生物合成基因簇显示出两部分的基因组结构，并受推定的Zn（II）（2）Cys（6）转录因子BcBot6正调控

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摘要

Botrydial (BOT) is a non-host specific phytotoxin produced by the polyphagous phytopathogenic fungus Botrytis cinerea. The genomic region of the BOT biosynthetic gene cluster was investigated and revealed two additional genes named Bcbot6 and Bcbot7. Analysis revealed that the G + C/A + T-equilibrated regions that contain the Bcbot genes alternate with A + T-rich regions made of relics of transposable elements that have undergone repeat-induced point mutations (RIP). Furthermore, BcBot6, a Zn(II)(2)Cys(6) putative transcription factor was identified as a nuclear protein and the major positive regulator of BOT biosynthesis. In addition, the phenotype of the Delta Bcbot6 mutant indicated that BcBot6 and therefore BOT are dispensable for the development, pathogenicity and response to abiotic stresses in the B. cinerea strain B05.10. Finally, our data revealed that B. pseudocinerea, that is also polyphagous and lives in sympatry with B. cinerea, lacks the ability to produce BOT. Identification of BcBot6 as the major regulator of BOT synthesis is the first step towards a comprehensive understanding of the complete regulation network of BUT synthesis and of its ecological role in the B. cinerea life cycle.
机译：Botrydial（BOT）是由多食性植物致病性真菌灰葡萄孢产生的非宿主特异性植物毒素。研究了BOT生物合成基因簇的基因组区域，发现了另外两个名为Bcbot6和Bcbot7的基因。分析表明，含有Bcbot基因的G + C / A + T平衡区与富含A + T的区域交替排列，这些区域由经过重复诱导的点突变（RIP）的转座子的遗物组成。此外，BcBot6，Zn（II）（2）Cys（6）推定的转录因子被确定为核蛋白和BOT生物合成的主要正向调节剂。另外，Delta Bcbot6突变体的表型表明，BcBot6和因此的BOT对于灰质芽孢杆菌菌株B05.10的发育，致病性和对非生物胁迫的响应都是可有可无的。最后，我们的数据显示，假单胞菌（B. pseudocinerea）也是多食性的，与灰葡萄孢菌（B. cinerea）共存，缺乏产生BOT的能力。鉴定BcBot6作为BOT合成的主要调节剂是全面了解BUT合成的完整调节网络及其在灰质芽孢杆菌生命周期中的生态作用的第一步。

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